Effects of Vonoprazan on Isolated Rat Lower Esophageal Sphincter and Ileum
Mert C. Ongun, Muhammed Yayla, Nihal Cetin, Hulagu Bariskaner · 2026
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Description
Ongun and colleagues tested in 2026 how vonoprazan, a newer stomach acid drug, acts on gut muscle taken from rats. The drug blocks acid well, but its direct effect on the muscle that moves food was unclear. The team studied the ring of muscle at the stomach entrance and pieces of small intestine in lab baths.
Vonoprazan relaxed both tissues more as the dose rose. After an hour in the drug, the gut pieces squeezed less when triggered by two chemicals that normally drive strong contractions. At the highest dose, the natural squeezing waves of the intestine shrank to about half their normal size. The results hint that the drug may slow gut movement as a side effect, though the team notes that tests in living animals and people must come first.
Catalog record
| CREATOR | Mert C. Ongun, Muhammed Yayla, Nihal Cetin, Hulagu Bariskaner |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 28 KB |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |