The Role of Adjuvant Nonavalent HPV Vaccination After LLETZ in Patients with Isolated CIN2: A Controlled Cohort Study
Vincenzo Pinto, Miriam Dellino, Marco Cerbone, Edoardo Di Naro, Achiropita Lepera, Silvio Tafuri, Gerardo Cazzato, Ettore Cicinelli · 2026
Read The Role of Adjuvant Nonavalent HPV Vaccination After LLETZ in Patients with Isolated CIN2: A Controlled Cohort Study by Vincenzo Pinto, Miriam Dellino, Marco Cerbone, Edoardo Di Naro, Achiropita Lepera, Silvio Tafuri, Gerardo Cazzato, Ettore Cicinelli (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13516261.txt.
Description
Pinto and colleagues evaluated whether human papillomavirus vaccination after surgical treatment of a precancerous cervical lesion lowers recurrence, in a 2026 cohort study from Italy. Women treated for grade 2 cervical intraepithelial neoplasia, abnormal cell changes that can precede cancer, face disease from lingering or fresh infections. Patients received the nine-type vaccine within a month of loop excision.
Pinto followed women who tested negative six months after surgery and compared them with unvaccinated historical controls. Recurrence of high-grade changes occurred in about two percent of vaccinated women versus about six percent of controls. That is a reduction near two thirds, though it did not reach statistical significance in this sample size. Recurrences in the vaccinated group appeared later, at eighteen months and four years, and involved both vaccine-covered and uncovered virus types. The authors call the effect clinically substantial while acknowledging the study was not powered to prove it.
Catalog record
| CREATOR | Vincenzo Pinto, Miriam Dellino, Marco Cerbone, Edoardo Di Naro, Achiropita Lepera, Silvio Tafuri, Gerardo Cazzato, Ettore Cicinelli |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 41 KB |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |