Sanzi Sijun Formula Alleviates Lipotoxic Liver Injury in Metabolic Dysfunction-Associated Steatotic Liver Disease via AMPK/SIRT1 Signaling Pathway
Junyao Ding, Tao Liu, Ping Huang, Lili Yang, Zhiwei Chen, Yining Xue, Yunlong Hua, Haiyan Song, Peiyong Zheng · 2026
Read Sanzi Sijun Formula Alleviates Lipotoxic Liver Injury in Metabolic Dysfunction-Associated Steatotic Liver Disease via AMPK/SIRT1 Signaling Pathway by Junyao Ding, Tao Liu, Ping Huang, Lili Yang, Zhiwei Chen, Yining Xue, Yunlong Hua, Haiyan Song, Peiyong Zheng (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13516140.txt.
Description
Junyao Ding and eight colleagues test a traditional Chinese formula against fatty liver disease in a 2026 study. The blend, Sanzi Sijun Formula, had shown early promise against the metabolic form of the disease, yet its working route was undefined. Chemical profiling first catalogued seventy-seven active ingredients. The team then fed mice a fat-rich diet with sugary water for ten weeks to build the disease, and treated them for eight weeks.
Treated mice lost body and liver weight, and their blood fats, liver enzymes, and inflammation signals all fell, while a protective hormone rose. Liver tissue showed less fat build-up, swelling, and immune invasion. Gene profiling pointed at lipid handling and one signalling route, AMPK with SIRT1, which lab tests on liver cells confirmed: blocking either switch partly cancelled the formula's benefit.
Catalog record
| CREATOR | Junyao Ding, Tao Liu, Ping Huang, Lili Yang, Zhiwei Chen, Yining Xue, Yunlong Hua, Haiyan Song, Peiyong Zheng |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 41 KB |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |