Ubiquitin-Dependent Regulation of Influenza A Virus Polymerase and vRNP Function: Mechanisms and Therapeutic Opportunities
Ren Cao, Feng Guo, Ting Huang, Yuxuan Zhang, You Chen, Jinwei Yuan, Tianyang Fu, Zhongfang Wang, Donglan Liu · 2026
Read Ubiquitin-Dependent Regulation of Influenza A Virus Polymerase and vRNP Function: Mechanisms and Therapeutic Opportunities by Ren Cao, Feng Guo, Ting Huang, Yuxuan Zhang, You Chen, Jinwei Yuan, Tianyang Fu, Zhongfang Wang, Donglan Liu (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13515672.txt.
Description
Cao and colleagues reviewed in 2026 how a small protein tag called ubiquitin controls the copying machine of influenza A virus. The virus copies itself with a three-part enzyme. Host cells add or remove these tags, and a tag can help the virus or block it, depending on where it lands.
The review gathers what is known about the cell enzymes that add or cut these tags, the exact sites they mark, and the kinds of tag chains they build. Some tags steady the viral enzyme and aid copying, while others mark viral parts for disposal or trigger immune alarms. The authors argue that drugs aimed at these host enzymes could back up current antivirals. The virus can mutate its own proteins to escape drugs, but it cannot change host targets as fast.
Catalog record
| CREATOR | Ren Cao, Feng Guo, Ting Huang, Yuxuan Zhang, You Chen, Jinwei Yuan, Tianyang Fu, Zhongfang Wang, Donglan Liu |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 51 KB |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |