Traumatic Brain Injury in the Omics Era: Plasma and Extracellular Vesicle Proteomic Signatures in Polytrauma
Liudmila Leppik, Birte Weber, Cora R. Schindler, Louise Funda, Marcus Krüger, Sebastian Proschinger, Dirk Henrich, Ingo Marzi · 2026
Read Traumatic Brain Injury in the Omics Era: Plasma and Extracellular Vesicle Proteomic Signatures in Polytrauma by Liudmila Leppik, Birte Weber, Cora R. Schindler, Louise Funda, Marcus Krüger, Sebastian Proschinger, Dirk Henrich, Ingo Marzi (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13515644.txt.
Description
Liudmila Leppik and seven colleagues hunt blood signatures of traumatic brain injury in badly hurt patients, in a 2026 proteomics study. Outcome after brain injury is hard to forecast, especially when the rest of the body is also injured. The team profiled proteins in plain blood plasma and in a fraction rich in tiny cell-made vesicles. Groups covered seventy-five patients: brain injury alone, brain injury with other trauma, and trauma without brain injury, plus twenty-four healthy volunteers.
The vesicle fraction yielded far more changed proteins than plain plasma. Most changes reflected body-wide injury rather than the brain wound itself, with plasma proteins pointing to metabolism and vesicle proteins to protein turnover. The vesicle pair also tracked consciousness scores and the need for brain surgery. Leppik's team names them as candidate markers for further study.
Catalog record
| CREATOR | Liudmila Leppik, Birte Weber, Cora R. Schindler, Louise Funda, Marcus Krüger, Sebastian Proschinger, Dirk Henrich, Ingo Marzi |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 37114 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |