Evaluation of the Therapeutic Effect of a Bovine-Derived Klebsiella pneumoniae Phage Endolysin on Mouse Mastitis Models
Zhuangkan Yan, Zhaomin Wu, Jieru Zhang, Yan Zeng, Chenfei Ma, Yin Wang, Zexiao Yang, Yixin Huang, Zhengzhong Luo, Kang Yong, Suizhong Cao, Xueping Yao · 2026
Read Evaluation of the Therapeutic Effect of a Bovine-Derived Klebsiella pneumoniae Phage Endolysin on Mouse Mastitis Models by Zhuangkan Yan, Zhaomin Wu, Jieru Zhang, Yan Zeng, Chenfei Ma, Yin Wang, Zexiao Yang, Yixin Huang, Zhengzhong Luo, Kang Yong, Suizhong Cao, Xueping Yao (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13515115.txt.
Description
Yan and colleagues produced in 2026 a bacteria-killing enzyme from a virus that attacks Klebsiella pneumoniae, a germ behind cow mastitis. The team expressed the phage enzyme, named Lysin K, in bacteria and purified it. They then tested its strength, stability, and effect in a mouse mastitis model.
Lysin K kept strong antibacterial activity across wide temperature and acidity ranges. Its minimum inhibitory concentration, the lowest dose that stops growth, was very low, and it stayed active in milk. It lysed three types of drug-resistant hypervirulent Klebsiella strains in the lab. In infected mice, treatment cut bacterial load sharply, eased inflammation, and restored normal mammary gland structure. The authors present Lysin K as a candidate for preventing and treating resistant mastitis without antibiotics.
Catalog record
| CREATOR | Zhuangkan Yan, Zhaomin Wu, Jieru Zhang, Yan Zeng, Chenfei Ma, Yin Wang, Zexiao Yang, Yixin Huang, Zhengzhong Luo, Kang Yong, Suizhong Cao, Xueping Yao |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 39 KB |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |