Factors Facilitating Adoption of Pharmacogenetic Testing by Prescribers of Antidepressants in Four US Health Systems: A Multi-Site Cross-Sectional PGx Implementation Science Study
Alice B. Popejoy, Deborah Cragun, Megan C. Roberts, Lisa M. Bendz, Sarah Gonzales, Susanne B. Haga, R. Ryanne Wu, Natasha J. Petry, Laura B. Ramsey, Ryley Uber, Kaniz Momin, Nina R. Sperber · 2026
Read Factors Facilitating Adoption of Pharmacogenetic Testing by Prescribers of Antidepressants in Four US Health Systems: A Multi-Site Cross-Sectional PGx Implementation Science Study by Alice B. Popejoy, Deborah Cragun, Megan C. Roberts, Lisa M. Bendz, Sarah Gonzales, Susanne B. Haga, R. Ryanne Wu, Natasha J. Petry, Laura B. Ramsey, Ryley Uber, Kaniz Momin, Nina R. Sperber (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13514951.txt.
Description
Popejoy and colleagues published a 2026 study on what gets doctors to order gene tests for antidepressants. Gene tests can flag patients likely to fare poorly on certain antidepressants. Use remains patchy across four United States health systems studied here. The team surveyed and interviewed prescribers, plus ten tested patients.
Prescribers broadly saw the tests as helpful for their patients' care. Cost at test time did not rank as a barrier for them. Yet workplace context still decided whether good will became orders. Logic-based analysis found minimal factor combos that sufficed for adoption. Fixing those few conditions may matter more than broad campaigns. Ten patients who had testing also shared their side of care. Two gene targets, CYP2D6 and CYP2C19, anchored the testing under study.
Catalog record
| CREATOR | Alice B. Popejoy, Deborah Cragun, Megan C. Roberts, Lisa M. Bendz, Sarah Gonzales, Susanne B. Haga, R. Ryanne Wu, Natasha J. Petry, Laura B. Ramsey, Ryley Uber, Kaniz Momin, Nina R. Sperber |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 41 KB |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |