Prunella vulgaris Compound Improves Sleep Architecture and Attenuates Hippocampal Injury in Insomnia Mice
Kai Wang, Haojia Zhang, Chang Zhou, Zijin Sun, Wei Shao, Kunjing Liu, Wenyuan Ma, Chunyu Wang, Xueqian Wang, Qingguo Wang, Yanyan Jiang, Fafeng Cheng · 2026
Read Prunella vulgaris Compound Improves Sleep Architecture and Attenuates Hippocampal Injury in Insomnia Mice by Kai Wang, Haojia Zhang, Chang Zhou, Zijin Sun, Wei Shao, Kunjing Liu, Wenyuan Ma, Chunyu Wang, Xueqian Wang, Qingguo Wang, Yanyan Jiang, Fafeng Cheng (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13514870.txt.
Description
Wang and colleagues report a 2026 study of a plant compound mixture from Prunella vulgaris, a traditional herb, tested on insomnia in mice. Sleeplessness was induced with a chemical that drains the brain's sleep signal serotonin. The team profiled the mixture's contents, recorded sleep with brain and muscle sensors, and examined the hippocampus, a memory region that insomnia injures.
Chemical profiling tentatively identified 198 constituents in the mixture. Treated mice slept better on both drug-induced sleep tests and overnight recordings, with sleep structure closer to normal. Their hippocampi showed less tissue damage, healthier transmitter balance, and lower activity of the NLRP3 inflammasome pathway, which drives a fiery form of cell death called pyroptosis. A traditional sleep remedy with a mapped chemistry and a named pathway gives modern insomnia research a testable lead beyond sedation.
Catalog record
| CREATOR | Kai Wang, Haojia Zhang, Chang Zhou, Zijin Sun, Wei Shao, Kunjing Liu, Wenyuan Ma, Chunyu Wang, Xueqian Wang, Qingguo Wang, Yanyan Jiang, Fafeng Cheng |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 49 KB |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |