Dimethyl Fumarate Enhances Venetoclax-Induced Cell Death by Inhibiting Mitochondrial Respiration and Cell Cycle Control in Colorectal Cancer
Simon Wagner, Anne Schroeder, Sara Martina Steinmann, Claudia Kunst, Kirstin Pollinger, Manuela Gunckel, Elisabeth Aschenbrenner, Martina Müller, Karsten Gülow · 2026
Read Dimethyl Fumarate Enhances Venetoclax-Induced Cell Death by Inhibiting Mitochondrial Respiration and Cell Cycle Control in Colorectal Cancer by Simon Wagner, Anne Schroeder, Sara Martina Steinmann, Claudia Kunst, Kirstin Pollinger, Manuela Gunckel, Elisabeth Aschenbrenner, Martina Müller, Karsten Gülow (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13514823.txt.
Description
Simon Wagner and eight colleagues report, in a 2026 lab study, a drug pairing that pushes colorectal cancer cells toward death. Colorectal cancer often survives by dodging the cell's built-in suicide programme, often through the protective protein Bcl-2. The team combined dimethyl fumarate, a redox-shifting drug already approved for multiple sclerosis, with venetoclax, which blocks Bcl-2 directly. Experiments centred on a widely used colorectal cancer cell line, HCT-116.
Dimethyl fumarate hobbled the cells' mitochondria, draining their energy currency and triggering recycling responses and cell-cycle arrest. Together, the two drugs deepened that stress, slowed growth, and held cells in a lasting arrest phase while switching off the cyclin proteins that drive division. Cell death rose most clearly when both drugs were given. Wagner's group frames the pairing as attractive because both drugs already exist in clinical use for other diseases.
Catalog record
| CREATOR | Simon Wagner, Anne Schroeder, Sara Martina Steinmann, Claudia Kunst, Kirstin Pollinger, Manuela Gunckel, Elisabeth Aschenbrenner, Martina Müller, Karsten Gülow |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 32 KB |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |