Ascorbic Acid Neuroprotection Against Hippocampal Injury and Gliosis Induced by E621 in Albino Rats Through Modulation of GFAP, Synaptophysin, and Caspase-3
Enas N. Morgan, Ayman M. Mousa, Rasha A. Elmansy, Hanan Seleem, Marwa M. Fawzi, Amany Refaat Mahmoud, Reham Abdulla Aboukhalil, Hagir H. T. Ahmed, Reem A. Younis, Tarek Hamdy Abd-ElHamid, Asmaa Jabeen, Ashwag Alsharidah, Samah M. Abozaid, Abdullah M. Alnuqaydan, Khaled E. A. Soliman, Enas Haridy Ahmed · 2026
Read Ascorbic Acid Neuroprotection Against Hippocampal Injury and Gliosis Induced by E621 in Albino Rats Through Modulation of GFAP, Synaptophysin, and Caspase-3 by Enas N. Morgan, Ayman M. Mousa, Rasha A. Elmansy, Hanan Seleem, Marwa M. Fawzi, Amany Refaat Mahmoud, Reham Abdulla Aboukhalil, Hagir H. T. Ahmed, Reem A. Younis, Tarek Hamdy Abd-ElHamid, Asmaa Jabeen, Ashwag Alsharidah, Samah M. Abozaid, Abdullah M. Alnuqaydan, Khaled E. A. Soliman, Enas Haridy Ahmed (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13514262.txt.
Description
Enas N. Morgan and co-authors test whether vitamin C can shield the rat hippocampus from harm caused by monosodium glutamate, the flavor enhancer coded E621, in 2026 work. Forty adult male rats split into four groups: plain control, vitamin alone, glutamate alone, and both together, with daily injections for thirty days. Brain tissue was stained for cell structure and for three markers covering scar-like support cell growth, synaptic protein, and a cell death enzyme, plus chemical measures of oxidative stress.
Glutamate alone produced shrunken, damaged granular cells and hollow spaces in the memory region, with all three markers strongly raised and oxidative balance tipped toward damage. Giving vitamin C alongside preserved much of the normal cell shape and eased the marker surge. The authors read vitamin C as a partial neuroprotective partner against additive-driven brain injury in this rat model.
Catalog record
| CREATOR | Enas N. Morgan, Ayman M. Mousa, Rasha A. Elmansy, Hanan Seleem, Marwa M. Fawzi, Amany Refaat Mahmoud, Reham Abdulla Aboukhalil, Hagir H. T. Ahmed, Reem A. Younis, Tarek Hamdy Abd-ElHamid, Asmaa Jabeen, Ashwag Alsharidah, Samah M. Abozaid, Abdullah M. Alnuqaydan, Khaled E. A. Soliman, Enas Haridy Ahmed |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 28 KB |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |