Quinoline and Phthalimide Substituted Silicon Phthalocyanines as Multi‐Target Inhibitors of Cholinesterases and Carbonic Anhydrases
Seda Ünlü, Zeynep Köksal, Kevser Kübra Kırboğa, Fikriye Tuncel Elmalı · 2026
Read Quinoline and Phthalimide Substituted Silicon Phthalocyanines as Multi‐Target Inhibitors of Cholinesterases and Carbonic Anhydrases by Seda Ünlü, Zeynep Köksal, Kevser Kübra Kırboğa, Fikriye Tuncel Elmalı (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13512772.txt.
Description
Seda Ünlü and co-authors synthesize two new silicon phthalocyanine compounds and test them as enzyme blockers in a 2026 paper. The ring-shaped molecules carry different side groups, a quinoline piece on one and a phthalimide piece on the other. The targets are four enzymes tied to memory loss and eye and metabolic disease.
Lab assays showed the phthalimide version blocked all four enzymes far more strongly, reaching under one micromolar against one carbonic anhydrase form. Computer docking agreed, showing extra hydrogen bonds for the stronger compound. Comparing the pair revealed how the side group drives potency. The authors present the winner as a promising multi-target lead for further drug work.
Catalog record
| CREATOR | Seda Ünlü, Zeynep Köksal, Kevser Kübra Kırboğa, Fikriye Tuncel Elmalı |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 44 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |