Linking EMT Dynamics to Cellular Plasticity: YAP/TAZ as Central Regulators Across Physiological and Pathological States
Laura Amicone, Carla Cicchini, Fabio Petti, Alessandra Marchetti · 2026
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Description
Laura Amicone, Carla Cicchini, Fabio Petti, and Alessandra Marchetti review two partner proteins, YAP and TAZ, as the central hub steering a cell identity program called epithelial-mesenchymal transition, in 2026 work. In this program, sheet-like epithelial cells loosen into wandering mesenchymal forms, a shift now seen as a sliding scale with hybrid states rather than an on-off switch. The pair reads mechanical, chemical, and metabolic cues from the cell's surroundings.
Through loops that feed forward and back with transition pathways, the hub locks in flexible states and runs context-fit gene programs. The same machinery serves embryo growth and wound repair, yet it also drives organ scarring and cancer spread when misused. The authors propose the hub model as a guide for drugs that would tune cell plasticity, aiming to block harmful shifts while sparing healing ones.
Catalog record
| CREATOR | Laura Amicone, Carla Cicchini, Fabio Petti, Alessandra Marchetti |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 47941 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |