Graph-Based Multi-Omics Integration Reveals Prognostic Histone Modification Reader Genes and Candidate Drug Targets in Colorectal Cancer
Xiangjun Cui, Sibo Xue, Peijun Jiang, Langlang Shi, Tianyang Tan, Yuhan Xu, Guoqing Liu, Hu Meng, Guojun Liu, Yongqiang Xing · 2026
Read Graph-Based Multi-Omics Integration Reveals Prognostic Histone Modification Reader Genes and Candidate Drug Targets in Colorectal Cancer by Xiangjun Cui, Sibo Xue, Peijun Jiang, Langlang Shi, Tianyang Tan, Yuhan Xu, Guoqing Liu, Hu Meng, Guojun Liu, Yongqiang Xing (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13512344.txt.
Description
Xiangjun Cui and nine co-authors mine multi-layer data for proteins that read chemical marks on histones, the spools that package DNA, and test their value in colorectal cancer, in 2026 work. These reader proteins help govern anti-tumor immunity, yet their joint roles in outlook and immune subtypes were murky. The team fused several omics layers through a graph attention network, then ran immune profiling and checked leads in outside cohorts.
Four core genes cleared every screen, showing steady outlook value and strong ties to anti-tumor immune activity. Core and helper genes sat in key metabolic and immune pathways. Single-cell readings, docking simulations, and other computer assays filled out their profiles, and one drug, sapitinib, was singled out for its fit against the encoded proteins. The authors offer the four-gene signature as a candidate marker set and drug target list for precision immune therapy.
Catalog record
| CREATOR | Xiangjun Cui, Sibo Xue, Peijun Jiang, Langlang Shi, Tianyang Tan, Yuhan Xu, Guoqing Liu, Hu Meng, Guojun Liu, Yongqiang Xing |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 78150 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |