Genome-Wide Identification of a Chromatin-Splicing Regulatory Axis Driven by DOT1L in MLL-Rearranged Acute Myeloid Leukemia
Qi Liu, Bowen Yang, Tianbao Li, Raven Garcia, Shengtong Han, Victor X. Jin · 2026
Read Genome-Wide Identification of a Chromatin-Splicing Regulatory Axis Driven by DOT1L in MLL-Rearranged Acute Myeloid Leukemia by Qi Liu, Bowen Yang, Tianbao Li, Raven Garcia, Shengtong Han, Victor X. Jin (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13512208.txt.
Description
Qi Liu, Bowen Yang, Tianbao Li, Raven Garcia, Shengtong Han, and Victor X. Jin test whether a signature chemical mark on DNA packaging also steers how genes are spliced in a rearranged form of acute myeloid leukemia, in 2026 work. The mark is placed by an enzyme called DOT1L and defines this leukemia subtype. The team profiled the mark and gene activity in samples from 24 rearranged-form patients, a few normal-form patients, and healthy donors.
Skipped gene segments clustered at marked spots in the rearranged samples. Blocking the enzyme reshaped skipping patterns, and many switched segments lost their local mark at the same time. Partner proteins included core splicing machinery, and about two thirds of shared switches overlapped a mark peak. A splicing score built from the switches split patients by survival in a large public cohort. The authors link the subtype's core lesion to splicing control.
Catalog record
| CREATOR | Qi Liu, Bowen Yang, Tianbao Li, Raven Garcia, Shengtong Han, Victor X. Jin |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 34 KB |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |