Complexities in the Diagnostic Evaluation and Treatment of Infant Hemophagocytic Lymphohistiocytosis
Reeja Raj, Ramya Ramakrishnan, Carlos Vargas, Muhammad Khalid, Gopi Mohan, David McCall, Amber Gibson, Branko Cuglievan, Cesar Nunez, Brandon Brown, Monica Bray, Miriam B. Garcia · 2026
Read Complexities in the Diagnostic Evaluation and Treatment of Infant Hemophagocytic Lymphohistiocytosis by Reeja Raj, Ramya Ramakrishnan, Carlos Vargas, Muhammad Khalid, Gopi Mohan, David McCall, Amber Gibson, Branko Cuglievan, Cesar Nunez, Brandon Brown, Monica Bray, Miriam B. Garcia (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13511909.txt.
Description
Reeja Raj and eleven co-authors present an infant case of a life-threatening overreaction of the immune system, in 2026 work. The syndrome, called HLH, floods the body with inflammatory signals and can shut down organs. An eight-month-old girl with influenza A arrived with seizures, a swollen liver and spleen, and low blood cell counts. Her ferritin and two immune signals ran very high, all pointing toward the syndrome.
Treatment aimed at the syndrome and at the virus began, yet she died of heart and lung failure. Gene testing found single-copy changes in two genes tied to immune control, hinting at a built-in predisposition. The team stresses how hard it is to separate inherited forms from infection-triggered ones at the bedside. Early gene and signal profiling, they argue, could steer how hard to suppress immunity in each case.
Catalog record
| CREATOR | Reeja Raj, Ramya Ramakrishnan, Carlos Vargas, Muhammad Khalid, Gopi Mohan, David McCall, Amber Gibson, Branko Cuglievan, Cesar Nunez, Brandon Brown, Monica Bray, Miriam B. Garcia |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 21424 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |