RNA Splicing Dysregulation in Parkinson’s Disease
Maria Giusy Bruno, Giacomo Menichetti, Angela Valentino, Aqsa Javaid, Francesca Belpinati, Alessandra Ruggiero, Maria Teresa Valenti, Giovanna Paolone, Fabio Cavaliere, Elisabetta Trabetti, Maria Grazia Romanelli, Cristina Bombieri · 2026
Read RNA Splicing Dysregulation in Parkinson’s Disease by Maria Giusy Bruno, Giacomo Menichetti, Angela Valentino, Aqsa Javaid, Francesca Belpinati, Alessandra Ruggiero, Maria Teresa Valenti, Giovanna Paolone, Fabio Cavaliere, Elisabetta Trabetti, Maria Grazia Romanelli, Cristina Bombieri (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13511882.txt.
Description
Bruno and colleagues reviewed in 2026 how faults in RNA splicing may help drive Parkinson's disease, a brain disorder that slowly kills the nerve cells that control movement. Splicing is the editing step that cuts and rejoins RNA copies of genes before they are used. Changed editing has been found in several genes tied to the disease.
The review covers splicing shifts in genes such as SNCA, LRRK2, MAPT, PRKN, and BIN1, and traces how those shifts disturb cell skeleton upkeep, energy production, and signal passing between nerve cells. It also looks at the RNA-binding proteins that run the editing, since their faults may spread the problem across many genes at once. The authors close with new lab models, among them tiny lab-grown brain-like organoids, that let researchers watch splicing go wrong in human-like tissue.
Catalog record
| CREATOR | Maria Giusy Bruno, Giacomo Menichetti, Angela Valentino, Aqsa Javaid, Francesca Belpinati, Alessandra Ruggiero, Maria Teresa Valenti, Giovanna Paolone, Fabio Cavaliere, Elisabetta Trabetti, Maria Grazia Romanelli, Cristina Bombieri |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 66 KB |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |