Molecular Basis of Adipose–Cardiac Crosstalk in Cardiovascular Diseases: From Mechanisms to Therapeutic Opportunities
Siqi Gan, Qixuan Zhang, Chan Zhang, Li Yan, Yue Yin, Heng Ma, Zihui Zhang · 2026
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Description
Siqi Gan, Qixuan Zhang, Chan Zhang, Li Yan, Yue Yin, Heng Ma, and Zihui Zhang review the two-way signaling between fat tissue and the heart in cardiovascular disease, in 2026 work. Fat is now seen as an active hormone and immune organ that talks to the heart through signal proteins, inflammatory messengers, metabolites, and tiny released packets. In health, that talk supports balance in metabolism and vessel function.
When fat tissue malfunctions, the same channels promote inflammation, scarring, vessel injury, and heart muscle reshaping. The review links fat depots and their secretions to artery hardening, heart failure, high blood pressure, diabetic heart muscle disease, and irregular heartbeat. It closes with candidate markers and treatment ideas aimed at the fat-heart axis, arguing that depot-specific signals could guide sharper diagnostic and drug choices for heart-metabolic disease.
Catalog record
| CREATOR | Siqi Gan, Qixuan Zhang, Chan Zhang, Li Yan, Yue Yin, Heng Ma, Zihui Zhang |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 56 KB |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |