Rg1-Loaded Tetrahedral DNA Nanostructures Attenuate Myocardial Ischemia–Reperfusion Injury by Suppressing Oxidative and Endoplasmic Reticulum Stress
Fengxia Lin, Jiamei Huang, Zetao Chen, Fanjia Zhong, Luhua Xu, Na Liu, Miao Gan, Haoran Yin, Zhiwen Li, Xiaoduo Zhang, Yinzhi Song, Xi Wang, Hui Zhuo, Hongcai Shang, Sheng Lin, Zhicong Zeng, Rongfeng Yang · 2026
Read Rg1-Loaded Tetrahedral DNA Nanostructures Attenuate Myocardial Ischemia–Reperfusion Injury by Suppressing Oxidative and Endoplasmic Reticulum Stress by Fengxia Lin, Jiamei Huang, Zetao Chen, Fanjia Zhong, Luhua Xu, Na Liu, Miao Gan, Haoran Yin, Zhiwen Li, Xiaoduo Zhang, Yinzhi Song, Xi Wang, Hui Zhuo, Hongcai Shang, Sheng Lin, Zhicong Zeng, Rongfeng Yang (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13511464.txt.
Description
Fengxia Lin and co-authors build a DNA carrier for a heart drug in this 2026 study. Ginsenoside Rg1 comes from ginseng and can protect heart tissue. The compound reaches the heart poorly on its own. The team loaded it onto a tiny pyramid-shaped DNA frame tagged with a heart-seeking peptide.
The loaded frames held a uniform size and stayed stable in fluid. In mice with heart attack damage, they gathered in heart tissue after injection. Treated mice survived better and kept stronger heart function. Stress markers in cells fell, and fewer heart cells died. The platform may boost other natural compounds the same way.
Catalog record
| CREATOR | Fengxia Lin, Jiamei Huang, Zetao Chen, Fanjia Zhong, Luhua Xu, Na Liu, Miao Gan, Haoran Yin, Zhiwen Li, Xiaoduo Zhang, Yinzhi Song, Xi Wang, Hui Zhuo, Hongcai Shang, Sheng Lin, Zhicong Zeng, Rongfeng Yang |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 60 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |