The Promise and Pursuit of MicroRNAs for Cancer Treatment
Camaleta Boothe, Arianna Rossi, Jenniffer Kalil, Jean J. Latimer · 2026
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Description
Camaleta Boothe, Arianna Rossi, Jenniffer Kalil, and Jean J. Latimer review tiny RNA strands called microRNAs as a possible biologic route to treating cancer, in 2026 work. These strands tune gene activity after genes are read, and cancers can lose the ones that hold growth back or gain extra copies of growth-pushing ones. Lab-made copies of the missing strands, called mimics, have curbed spread, growth, and cell survival in dishes, animals, and early trials.
A single mimic can strike several genes in one pathway at once, and some can restore response to drugs that had stopped working. Bare strands break down fast, so chemical tweaks add staying power, and carrier particles help them cross cell walls, though carriers can stir inflammation. A tweak swapping one building block for a drug-like version also eased entry. The authors trace lessons from an approved sister therapy as a roadmap.
Catalog record
| CREATOR | Camaleta Boothe, Arianna Rossi, Jenniffer Kalil, Jean J. Latimer |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 22952 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |