CCL2 in Rheumatoid Arthritis: A Context-Dependent Cross-Cellular Node Serving as Biomarker and Therapeutic Target
Bowen Shi, Ke Bai, Renping Liu, Nanzhen Kuang, Wei Cai · 2026
Read CCL2 in Rheumatoid Arthritis: A Context-Dependent Cross-Cellular Node Serving as Biomarker and Therapeutic Target by Bowen Shi, Ke Bai, Renping Liu, Nanzhen Kuang, Wei Cai (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13510963.txt.
Description
Bowen Shi and co-authors present a 2026 review on a signaling protein called CCL2 in rheumatoid arthritis. CCL2 talks to many cell types in the joint and helps draw immune cells into the tissue. Lab studies link it to a web of inflammation that spans the joint lining, bone-eroding cells, and blood vessels.
Drugs that block the CCL2 pathway calm arthritis in animals but have not given steady benefit in patients. Human studies still find value in measuring CCL2 in blood. Its levels may help flag early risk, grade disease activity, judge treatment response, and spot lung complications. The authors frame CCL2 as a context-dependent hub: better as a marker than as a drug target so far.
Catalog record
| CREATOR | Bowen Shi, Ke Bai, Renping Liu, Nanzhen Kuang, Wei Cai |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 54 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |