Cbx3a/HP1γ Deficiency Disrupts Meiotic Progression and Triggers Germ Cell Apoptosis in Nile Tilapia
Hongqin Jian, Jiahong Wu, Ruijuan Feng, Liang Zhang, Li Zhou, Xingyong Liu · 2026
Read Cbx3a/HP1γ Deficiency Disrupts Meiotic Progression and Triggers Germ Cell Apoptosis in Nile Tilapia by Hongqin Jian, Jiahong Wu, Ruijuan Feng, Liang Zhang, Li Zhou, Xingyong Liu (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13510707.txt.
Description
Jian and colleagues report a 2026 study of a gene regulator in Nile tilapia sperm production, using gene editing in this farmed fish. The protein, Cbx3a or HP1γ, helps organize packed DNA and guides meiosis, the cell division that makes sperm. The team knocked out one copy and watched reproduction.
The protein was found in early germ cells and stayed present through sperm development. Without it, germ cells died by apoptosis, meiosis stalled, and sperm came out fewer and weaker, with short tails and poor swimming. Fertility was badly compromised as a result. The gene's job survived deep evolution, and tilapia breeding must handle it with care.
Catalog record
| CREATOR | Hongqin Jian, Jiahong Wu, Ruijuan Feng, Liang Zhang, Li Zhou, Xingyong Liu |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 33 KB |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |