Early EGFR Inhibition Triggers Actionable Tumor and Microenvironmental Remodeling in Lung Cancer
Aaron C. Tan, Jia Chi Yeo, Jacob J.S. Alvarez, Mengyuan Pang, Yu Amanda Guo, Regina Hoo, Angela M. Takano, Boon-Hean Ong, Denise Goh, Joe Yeong, Zhengwei Wu, Ju Yuan, S. Shathishwaran, Ngak Leng Sim, Khi Pin Chua, Wai Leong Tam, Lan Ying Wang, Dawn P.X Lau, Stephanie P. Saw, Amit Jain, Gillianne G. Lai, Wan Ling Tan, Mei Kim Ang, Quan Sing Ng, Ravindran Kanesvaran, Darren W. Lim, Anders J. Skanderup, Daniel S. Tan · 2026
Read Early EGFR Inhibition Triggers Actionable Tumor and Microenvironmental Remodeling in Lung Cancer by Aaron C. Tan, Jia Chi Yeo, Jacob J.S. Alvarez, Mengyuan Pang, Yu Amanda Guo, Regina Hoo, Angela M. Takano, Boon-Hean Ong, Denise Goh, Joe Yeong, Zhengwei Wu, Ju Yuan, S. Shathishwaran, Ngak Leng Sim, Khi Pin Chua, Wai Leong Tam, Lan Ying Wang, Dawn P.X Lau, Stephanie P. Saw, Amit Jain, Gillianne G. Lai, Wan Ling Tan, Mei Kim Ang, Quan Sing Ng, Ravindran Kanesvaran, Darren W. Lim, Anders J. Skanderup, Daniel S. Tan (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13510642.txt.
Description
Tan and colleagues in Singapore gave in 2026 a short course of a lung cancer drug to thirteen patients, then read how their tumors reshaped in the first weeks. The drug blocks a growth switch that the tumors carry in flawed form. All had early stage lung tumors set for cut out. Pills ran a month or more pre cut. Tumor and rim tissue then got deep gene and place reads, set against drug free tumors.
All tumors shrank or held still, and near half dropped a stage. No known drug proof flaw showed up in that span. The tumors grew less pure, with more sound rim in the mix. Immune and flare genes woke, and the fuel path flipped from fast sugar burn to slow air burn. The team sees fresh weak spots to pair with the drug.
Catalog record
| CREATOR | Aaron C. Tan, Jia Chi Yeo, Jacob J.S. Alvarez, Mengyuan Pang, Yu Amanda Guo, Regina Hoo, Angela M. Takano, Boon-Hean Ong, Denise Goh, Joe Yeong, Zhengwei Wu, Ju Yuan, S. Shathishwaran, Ngak Leng Sim, Khi Pin Chua, Wai Leong Tam, Lan Ying Wang, Dawn P.X Lau, Stephanie P. Saw, Amit Jain, Gillianne G. Lai, Wan Ling Tan, Mei Kim Ang, Quan Sing Ng, Ravindran Kanesvaran, Darren W. Lim, Anders J. Skanderup, Daniel S. Tan |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 58 KB |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |