Detection of TDP-43 Proteinopathies in Brain and Cerebrospinal Fluid Using Seed Amplification Assay
Katsuya Satoh, Mika Inada Shimamura, Takeshi Fujimoto, Michio Kitayama, Akio Akagi, Yasushi Iwasaki, Yuu Satoh, Katsuhiro Ichinose, Akira Satoh, Ikuko Takahashi Iwata, Ichiro Yabe · 2026
Read Detection of TDP-43 Proteinopathies in Brain and Cerebrospinal Fluid Using Seed Amplification Assay by Katsuya Satoh, Mika Inada Shimamura, Takeshi Fujimoto, Michio Kitayama, Akio Akagi, Yasushi Iwasaki, Yuu Satoh, Katsuhiro Ichinose, Akira Satoh, Ikuko Takahashi Iwata, Ichiro Yabe (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13510334.txt.
Description
Katsuya Satoh and co-authors simplify a lab test that detects the seeding activity of a misfolded protein tied to ALS and a dementia syndrome, in a 2026 study. The protein, TDP-43, clumps in nerve cells in both diseases, and tests that amplify its seeds can flag the disease process in spinal fluid. Older versions needed a slow antibody capture step that limits routine use.
Their streamlined version skipped that step and still flagged most patients with the combined ALS-dementia picture, and half of dementia-only patients. It was nearly always negative in two hundred control samples. Positive patients also carried higher levels of a nerve damage marker. The authors offer the assay as a scalable base for wider validation.
Catalog record
| CREATOR | Katsuya Satoh, Mika Inada Shimamura, Takeshi Fujimoto, Michio Kitayama, Akio Akagi, Yasushi Iwasaki, Yuu Satoh, Katsuhiro Ichinose, Akira Satoh, Ikuko Takahashi Iwata, Ichiro Yabe |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 27 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |