Interpreting the Efficacy of Liposomal Bupivacaine in Fascial Plane Blocks for Elderly Patients: A Methodological Reappraisal [Letter]
Hongyu Gai, Ying Hou, Yang Yu · 2026
Read Interpreting the Efficacy of Liposomal Bupivacaine in Fascial Plane Blocks for Elderly Patients: A Methodological Reappraisal [Letter] by Hongyu Gai, Ying Hou, Yang Yu (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13510218.txt.
Description
Hongyu Gai, Ying Hou, and Yang Yu wrote a 2026 letter questioning a trial of long acting pain relief for nerve blocks in older patients. The trial compared a liposomal form of bupivacaine with the plain drug and with no block, for abdominal wall blocks in elderly patients having keyhole hernia repair. The trial's authors claimed better pain sparing and faster recovery for the liposomal form.
The letter argues the trial was sized to detect any block versus none, not the liposomal form against the plain drug. Under the authors' own assumptions, both active groups were expected to use the same amount of morphine. The actual gap between the two drug groups was small and not significant. The writers urge care before adopting the costlier drug.
Catalog record
| CREATOR | Hongyu Gai, Ying Hou, Yang Yu |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 4 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |