Unraveling Effects and Pharmacological Mechanisms of Phellodendrine on Inflammatory Bowel Disease
Yufeng Xie, Ziyi Zhou, Xuqianzi Wu, Jiayin Teng, Xiaorun Zhang, Yue Sun, Lixin Chen, Lijian Ding, Wei Yuan · 2026
Read Unraveling Effects and Pharmacological Mechanisms of Phellodendrine on Inflammatory Bowel Disease by Yufeng Xie, Ziyi Zhou, Xuqianzi Wu, Jiayin Teng, Xiaorun Zhang, Yue Sun, Lixin Chen, Lijian Ding, Wei Yuan (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13510209.txt.
Description
Yufeng Xie and eight co-authors test a plant compound called phellodendrine in a zebrafish model of inflammatory bowel disease, in 2026 work. The disease brings lasting gut inflammation, and current drugs often work weakly or carry heavy side effects. The team triggered bowel inflammation in zebrafish with a chemical irritant, then measured immune cell entry, gene activity, gut barrier strength, microbes, and oxidative stress with and without the compound.
Treated fish showed less immune cell invasion and a shift in immune cells toward a calmer state, with inflammatory genes turned down and protective ones turned up. The gut barrier held better, with more mucus protein, more mucus-making cells, and less leaking. Harmful microbes fell while helpful ones rose, and oxidative stress eased. Computer pathway work pointed to a few inflammatory routes and six candidate target genes for follow-up.
Catalog record
| CREATOR | Yufeng Xie, Ziyi Zhou, Xuqianzi Wu, Jiayin Teng, Xiaorun Zhang, Yue Sun, Lixin Chen, Lijian Ding, Wei Yuan |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 46 KB |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |