Transcriptomic Study of Mechanism Driving Conjunctival Fibrosis Following Glaucoma Filtration Surgery
Zoe Pasvanis, Antony Boynes, Roy C. K. Kong, Elsa C. Chan, Raymond C. B. Wong, Jennifer Fan Gaskin · 2026
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Description
Pasvanis and colleagues charted in 2026 how a growth signal switches eye fibroblasts into scar-forming cells. The culprit is the myofibroblast, a contractile scar cell arising from Tenon's fibroblasts under the signal TGFβ. The team treated human Tenon's fibroblasts from three surgical patients with TGFβ1 for five days and profiled all gene activity.
They found 3,362 genes changed activity, with more switched down than up. Pathways involved covered scar-cell formation, TGFβ signalling, collagen and matrix organisation, cell identity change, and cell cycle control. Named genes rising included LDLRAD4, CDKN2B, FZD8, and MYOZ1, while SOD3 and LTBP4 fell, among others. The map gives drug hunters specific targets for anti-scarring therapy after glaucoma surgery. The authors present the dataset as a detailed characterisation of the transition.
Catalog record
| CREATOR | Zoe Pasvanis, Antony Boynes, Roy C. K. Kong, Elsa C. Chan, Raymond C. B. Wong, Jennifer Fan Gaskin |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 31 KB |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |