ISUP Grade Group Migration Between Prostate Biopsy and Radical Prostatectomy: A Systematic Review of Emerging Predictors
Victor Pasecinic, Dorin Novacescu, Flavia Zara, Cristina-Stefania Dumitru, Antonia Armega-Anghelescu, Silviu Latcu, Alin Cumpanas, Radu Caprariu, Pavel Banov, Ademir Horia Stana, Radu Gheorghe Dan, Raluca Dumache · 2026
Read ISUP Grade Group Migration Between Prostate Biopsy and Radical Prostatectomy: A Systematic Review of Emerging Predictors by Victor Pasecinic, Dorin Novacescu, Flavia Zara, Cristina-Stefania Dumitru, Antonia Armega-Anghelescu, Silviu Latcu, Alin Cumpanas, Radu Caprariu, Pavel Banov, Ademir Horia Stana, Radu Gheorghe Dan, Raluca Dumache (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13509513.txt.
Description
Pasecinic and colleagues synthesised in 2026 the evidence on prostate cancer grade changing between biopsy and surgery. Grade Group discordance affects a quarter to half of men with localised disease and steers choices about surveillance and nerve-sparing surgery. Thirty-seven primary studies and eight earlier reviews were included, with bias and certainty ratings applied.
Agreement between biopsy and final grade ranged from forty-four to about seventy percent across studies. Upgrading ranged widely, from fourteen to sixty-seven percent, and downgrading from five to twenty-six percent. The lowest biopsy grade carried the highest upgrading risk, at fifty-five to sixty-seven percent. Four predictors earned moderate certainty: MRI scan category, biopsy approach, a PET scan uptake value, and PSA density. The authors say knowing migration risk can sharpen counselling before surgery.
Catalog record
| CREATOR | Victor Pasecinic, Dorin Novacescu, Flavia Zara, Cristina-Stefania Dumitru, Antonia Armega-Anghelescu, Silviu Latcu, Alin Cumpanas, Radu Caprariu, Pavel Banov, Ademir Horia Stana, Radu Gheorghe Dan, Raluca Dumache |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 94 KB |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |