Exploratory Pharmacokinetic Characterization of Enrofloxacin and Ciprofloxacin in Plasma and Interstitial Fluid of Dogs: Nonlinear Mixed-Effects Modeling and PK/PD Target Attainment Analysis
Patrik Mag, Zoltán Somogyi, Andrea Kertenics, Márton Kovács, Pál Szabó, Ákos Jerzsele · 2026
Read Exploratory Pharmacokinetic Characterization of Enrofloxacin and Ciprofloxacin in Plasma and Interstitial Fluid of Dogs: Nonlinear Mixed-Effects Modeling and PK/PD Target Attainment Analysis by Patrik Mag, Zoltán Somogyi, Andrea Kertenics, Márton Kovács, Pál Szabó, Ákos Jerzsele (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13509500.txt.
Description
Patrik Mag and five co-authors track how an antibiotic and its active breakdown product move through dogs, in 2026 work. Nine healthy beagles received one high oral dose, and the team sampled blood plus the fluid that bathes tissues over a full day. That tissue fluid matters because infections often sit outside blood vessels, where drug levels can differ from blood readings.
Both drugs peaked later and reached higher total exposure in tissue fluid than in blood. Computer models built from the data described both settings well, and simulations with thousands of virtual dogs showed treatment targets were met more often in tissue fluid. At stricter targets, the highest germ level still covered was four times higher in tissue fluid than in blood. The authors say blood alone may understate protection at infection sites.
Catalog record
| CREATOR | Patrik Mag, Zoltán Somogyi, Andrea Kertenics, Márton Kovács, Pál Szabó, Ákos Jerzsele |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 70985 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |