Mass Spectrometry-Based Comparative Evaluation of Forced Glycation Profiles of Therapeutic Monoclonal Antibodies
Ceren Pamukcu, Ahmet Emin Atik · 2026
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Description
Ceren Pamukcu and Ahmet Emin Atik compare how sugar attaches to therapeutic antibodies under stress, in a 2026 lab study. Sugar attachment, called glycation, can add unwanted variety to these drugs and matters when firms develop copy versions known as biosimilars. The pair studied one original antibody drug and three biosimilar versions, all aimed at the same inflammation target, after a week in a strong sugar solution.
Mass readings showed a near-identical mass gain in all four products, pointing to three sugar units added to most molecules. Detailed mapping found nine sites where sugar attached, with three hot spots carrying most of the change and the rest barely touched. Total glycation levels sat close together across products despite different making processes. The authors present the paired method as a sound way to compare such drugs.
Catalog record
| CREATOR | Ceren Pamukcu, Ahmet Emin Atik |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 37 KB |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |