Incident Cognitive Impairment in Nonobese Versus Obese Adults Aged 50 Years or Older With Metabolic Dysfunction‐Associated Steatotic Liver Disease: A Propensity Score–Matched Cohort Study
Akram Alnounou, Mohammad Alabbas, Riddhi Machchhar, EzzEIDien A Ibrahim, Mohammad Alali, Ahmad Alhusen, Syed-Mohammed Jafri, Basile Njei, Sreeja Dattachoudhury · 2026
Read Incident Cognitive Impairment in Nonobese Versus Obese Adults Aged 50 Years or Older With Metabolic Dysfunction‐Associated Steatotic Liver Disease: A Propensity Score–Matched Cohort Study by Akram Alnounou, Mohammad Alabbas, Riddhi Machchhar, EzzEIDien A Ibrahim, Mohammad Alali, Ahmad Alhusen, Syed-Mohammed Jafri, Basile Njei, Sreeja Dattachoudhury (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13509417.txt.
Description
Akram Alnounou and co-authors compare, in a 2026 study, new thinking problems in older adults with fatty liver disease who are not obese versus those who are. Fatty liver tied to metabolic dysfunction may carry an outsized risk to the brain in leaner patients. Whether body shape changes that risk within the disease was unresolved.
The team ran a retrospective study in a large federated health record network. Adults aged fifty and older with a first diagnosis between 2016 and 2022 were split by body mass index. The non obese band ran from the healthy range up through overweight, and the obese band sat above it. Underweight patients were excluded. Pairs were matched on a propensity score to balance the groups. The outcome was a bundle of new thinking problems, from mild impairment onward. The design isolates body shape as the contrast of interest.
Catalog record
| CREATOR | Akram Alnounou, Mohammad Alabbas, Riddhi Machchhar, EzzEIDien A Ibrahim, Mohammad Alali, Ahmad Alhusen, Syed-Mohammed Jafri, Basile Njei, Sreeja Dattachoudhury |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 49 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |