Baicalin-Chlorogenic Acid Self-Assembled Nanoparticles: A Carrier-Free Nano-Formulation for the Treatment of Acute Pharyngitis
Xinyi Wang, Zhouyang Qian, Zhenchao Gong, Lu Sun, Liang Feng, Yanjun Yang, Xiaobin Jia · 2026
Read Baicalin-Chlorogenic Acid Self-Assembled Nanoparticles: A Carrier-Free Nano-Formulation for the Treatment of Acute Pharyngitis by Xinyi Wang, Zhouyang Qian, Zhenchao Gong, Lu Sun, Liang Feng, Yanjun Yang, Xiaobin Jia (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13509274.txt.
Description
Wang and colleagues report a 2026 study of a carrier-free nanoparticle for treating acute pharyngitis. The condition is a sudden, painful throat inflammation, and the particles are made from two plant compounds, baicalin and chlorogenic acid. Baicalin fights inflammation but dissolves poorly in water and absorbs badly. So the team let the two compounds assemble into nanoparticles by themselves, an idea drawn from a traditional Chinese formula.
In immune cells provoked with bacterial toxin, the particles lowered nitric oxide, reactive oxygen species, and two inflammatory signals. In rats with sore throats, the oral particles raised baicalin levels in the body more than the plain compounds did. Throat tissue also looked healthier, and inflammatory signals fell in blood and tissue. The effect was tied to calming a key inflammatory pathway in cells.
Catalog record
| CREATOR | Xinyi Wang, Zhouyang Qian, Zhenchao Gong, Lu Sun, Liang Feng, Yanjun Yang, Xiaobin Jia |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 66 KB |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |