Comprehensive Phytopharmacological Profiling of Polygonum aviculare L.: Antioxidant, Anti-Inflammatory, and α-Glucosidase Inhibitory Activities of Bioactive Constituents with Molecular Docking and In Silico Drug-Likeness Analysis

Description

Yuen-Sing Lee, Sin-Min Li, Hui-Ju Chen, and Jih-Jung Chen profile the chemistry of a traditional herb, Polygonum aviculare, hunting its active ingredients, in 2026 work. The plant has long served in folk medicine for inflammation and urine flow. Extracts from its above-ground parts were tested for antioxidant power, blood sugar enzyme blocking, and calming of inflammation. Pure compounds were then isolated and run through the same tests. Computer docking checked how the winners might grip their target enzymes, and a drug-likeness screen judged their promise.

Five compounds beat the standard antioxidant control by a wide margin. One, kaempferol, blocked the sugar enzyme hundreds of times more strongly than the clinic drug used as comparison. It also quieted two inflammation drivers in immune cells and nudged those cells toward a healing state. A sister compound, quercetin, matched it on several tests.

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Source: https://europepmc.org/article/MED/PMC13509247