Region-Specific Proteomic Profiles of Extracellular Vesicles (EVs) Derived from Human Macular and Peripheral RPE-Choroid Explants
Jingwen Zeng, Jialing Zhang, James Schulz, Azhar Dzulhadj B. Arafah, Sora Lee, Michelle Yam, Yi Shen, Fanfan Zhou, Ting Zhang, Mark C. Gillies, Ling Zhu · 2026
Read Region-Specific Proteomic Profiles of Extracellular Vesicles (EVs) Derived from Human Macular and Peripheral RPE-Choroid Explants by Jingwen Zeng, Jialing Zhang, James Schulz, Azhar Dzulhadj B. Arafah, Sora Lee, Michelle Yam, Yi Shen, Fanfan Zhou, Ting Zhang, Mark C. Gillies, Ling Zhu (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13509229.txt.
Description
Zeng and colleagues compare tiny parcels released by the back of the human eye in 2026 research on retinal disease. These parcels, called extracellular vesicles, carry proteins between cells and reflect the state of the tissue that made them. The team collected vesicles from the macula, the central region used for sharp vision, and from the peripheral retina of donor eyes, asking whether their cargo differs by region.
Explants from four non-diseased donor eyes were cultured, and vesicles were isolated and checked by electron microscopy and particle tracking. The particles measured between 119 and 140 nanometers across, confirming they were small vesicles in both regions. Protein profiling then showed a clear regional split: macular and peripheral samples separated in both the vesicle data and the surrounding fluid. Pathway analysis linked macular vesicle proteins to functions that may explain why the macula is prone to disease.
Catalog record
| CREATOR | Jingwen Zeng, Jialing Zhang, James Schulz, Azhar Dzulhadj B. Arafah, Sora Lee, Michelle Yam, Yi Shen, Fanfan Zhou, Ting Zhang, Mark C. Gillies, Ling Zhu |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 41 KB |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |