Cumulative incidence and prognostic factors for leukemic transformation in chronic myelomonocytic leukemia: a competing risk analysis
Jungao Huang, Chaoqiang Zheng, Yulan Liu, Changhao Li, Xiaoqin Xin · 2026
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Description
Jungao Huang and four co-authors re-count how often a chronic leukemia turns acute, using a method that handles deaths fairly, in 2026 work. In chronic myelomonocytic leukemia, transformation to acute leukemia is the pivotal event. Standard survival math can overstate that risk by treating deaths before transformation as mere dropouts. Records covered 102 patients treated at one Chinese hospital from 2014 to 2025. The team compared the fairer competing-risk count with the classic estimate, and hunted predictors with matching models.
Fifty-four patients, just over half, transformed during follow-up, while seven died first. The fair count put transformation at about forty-seven percent by one year and about seventy-four percent by three years. Classic math overshot each figure by roughly five to six percent in relative terms. Supportive care alone and chemotherapy each carried higher transformation hazards than modern targeted drugs in this non-random data.
Catalog record
| CREATOR | Jungao Huang, Chaoqiang Zheng, Yulan Liu, Changhao Li, Xiaoqin Xin |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 44053 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |