CCL5 and CD11b-fibrin interactions regulate microglia migration and morphology in hyperinflammatory experimental cerebral malaria
Nadia D Domingo, Olivia D Solomon, Paula Villarreal, Florentin Aussenac, Difernando Vanegas, Mark Joseph Endrino, Andrew S Mendiola, Lucinda Puebla-Clark, Komi Gbedande, Astrid E Cardona, Katerina Akassoglou, Matthew J Flick, Gracie Vargas, Robin Stephens · 2026
Read CCL5 and CD11b-fibrin interactions regulate microglia migration and morphology in hyperinflammatory experimental cerebral malaria by Nadia D Domingo, Olivia D Solomon, Paula Villarreal, Florentin Aussenac, Difernando Vanegas, Mark Joseph Endrino, Andrew S Mendiola, Lucinda Puebla-Clark, Komi Gbedande, Astrid E Cardona, Katerina Akassoglou, Matthew J Flick, Gracie Vargas, Robin Stephens (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13508551.txt.
Description
Nadia Domingo leads a fourteen-author team studying how brain immune cells move toward clotted vessels in cerebral malaria, in 2026 mouse work. Cerebral malaria kills by inflaming and clogging brain vessels, and clots rich in the protein fibrin are a hallmark. Earlier work by the group showed that removing microglia, the brain's resident immune cells, made clotting and disease worse, while thinning blood reduced their buildup and saved animals.
Live two-photon imaging through the skull and cell sorting tracked microglia, T cells, and monocytes in infected mice. Tools included a blocker for a draw signal called CCL5, antibodies that jam cell grip proteins, and mutant mice lacking clotting pieces or the grip partner on microglia. A peptide that breaks the grip between microglia and fibrin tested that contact directly. The work maps the choreography that decides whether immune help reaches clotted brain vessels.
Catalog record
| CREATOR | Nadia D Domingo, Olivia D Solomon, Paula Villarreal, Florentin Aussenac, Difernando Vanegas, Mark Joseph Endrino, Andrew S Mendiola, Lucinda Puebla-Clark, Komi Gbedande, Astrid E Cardona, Katerina Akassoglou, Matthew J Flick, Gracie Vargas, Robin Stephens |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 67002 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |