Paraventricular oxytocin neurons attenuate post-ischemic brain injury by suppressing microglia-mediated neuroinflammation
Rui Liu, Xinyu Yang, Haozhi Gong, Huijie Fang, Xuebing Feng, Jiayao Li, Wentao Gao, Xiaoting Liang, Yanping Shen, Yubo Wang, Wei Wang, Jiaqi Jin, Liqun Jiao · 2026
Read Paraventricular oxytocin neurons attenuate post-ischemic brain injury by suppressing microglia-mediated neuroinflammation by Rui Liu, Xinyu Yang, Haozhi Gong, Huijie Fang, Xuebing Feng, Jiayao Li, Wentao Gao, Xiaoting Liang, Yanping Shen, Yubo Wang, Wei Wang, Jiaqi Jin, Liqun Jiao (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13508365.txt.
Description
Rui Liu leads a thirteen-author team testing whether activating oxytocin neurons in the brain shields tissue after a stroke, in 2026 mouse work. Oxytocin is a hormone messenger made in a small brain region called the paraventricular nucleus. Inflammation driven by overactive immune cells worsens stroke injury, and oxytocin has calmed inflammation in other settings. The stroke model briefly blocked a brain artery. The team measured oxytocin in several fluids, then used a genetic switch to fire up those neurons in special mice.
Oxytocin levels fell after stroke in brain tissue, blood, and spinal fluid, while its receptor rose near the injury. Switching the neurons on raised oxytocin again, shrank the damaged area, and improved function. Gene reading flagged a calming of an immune draw signal as a key change. The work suggests a built-in brain circuit that can be nudged to limit stroke damage.
Catalog record
| CREATOR | Rui Liu, Xinyu Yang, Haozhi Gong, Huijie Fang, Xuebing Feng, Jiayao Li, Wentao Gao, Xiaoting Liang, Yanping Shen, Yubo Wang, Wei Wang, Jiaqi Jin, Liqun Jiao |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 59460 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |