Neural peer pressure: intercellular dynamics and emergent phenotypes in the mosaic Rett syndrome brain
Jarno Koetsier, Chris P Reutelingsperger, Leopold MG Curfs, Lars MT Eijssen, Nasim Bahram Sangani · 2026
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Description
Jarno Koetsier and four co-authors argue that Rett syndrome brains should be studied as a talking mix of two cell types, not as single cells acting alone, in 2026 work. In females, each cell switches off one X chromosome at random early in development. In this X-linked disorder, that leaves a mosaic: some brain cells use the faulty gene copy and others use the healthy one. The authors review how these neighbors swap small packets, molecules, and direct contact signals.
That crosstalk can create behaviors neither cell group would show alone. Evidence points to a spectrum of in-between cell states rather than two tidy camps. Healthy cells may soften or worsen the faults of their mutant neighbors, and vice versa. Shifting focus to group dynamics, the authors say, could explain puzzling features of mosaic disorders. It could open treatment ideas that work through the healthy cell population.
Catalog record
| CREATOR | Jarno Koetsier, Chris P Reutelingsperger, Leopold MG Curfs, Lars MT Eijssen, Nasim Bahram Sangani |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 33036 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |