Synergistic interaction between the macrophage polarizing signals IL-4 and IFNγ is controlled by the STAT6/STAT1/IRF1 axis
Zsófia Varga, Anna Poscher, Eszter Anna Váradi, Gyöngyi Cinege, Antal Izsán, Edina Erdős, Bernadett Benyhe-Kis, Anna Zsuzsanna Tihanyi, Petros Tzerpos, Krisztián Bene, László Halász, Nikolett Gémes, Patrícia Neuperger, Márta Tóth, Ede Migh, Szilárd Póliska, Gábor J Szebeni, Jolán E Walter, Bence Dániel, Bálint Csörgő, László Nagy, Zsolt Czimmerer · 2026
Read Synergistic interaction between the macrophage polarizing signals IL-4 and IFNγ is controlled by the STAT6/STAT1/IRF1 axis by Zsófia Varga, Anna Poscher, Eszter Anna Váradi, Gyöngyi Cinege, Antal Izsán, Edina Erdős, Bernadett Benyhe-Kis, Anna Zsuzsanna Tihanyi, Petros Tzerpos, Krisztián Bene, László Halász, Nikolett Gémes, Patrícia Neuperger, Márta Tóth, Ede Migh, Szilárd Póliska, Gábor J Szebeni, Jolán E Walter, Bence Dániel, Bálint Csörgő, László Nagy, Zsolt Czimmerer (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13507861.txt.
Description
Varga and colleagues discovered that two immune signals famous for pushing macrophages in opposite directions can instead cooperate on a shared set of genes. Interferon-gamma drives macrophages toward attack mode, while interleukin-4 drives healing mode, and the two antagonize each other. The team combined gene activity mapping, chromatin profiling, and gene editing to find where synergy arises.
Varga found that co-exposure produced an intermediate cell state with a cohort of genes switched on together more than by either signal alone. The effect depended on both signals' transcription factors binding together at regulatory regions opened by the partner signal, with a cofactor protein needed. Deleting a factor or its binding sites erased the synergy, and a third factor induced by interferon proved indispensable for the program. Single-cell data from a mouse breast tumor confirmed a macrophage subset carrying this combined signature inside tumors.
Catalog record
| CREATOR | Zsófia Varga, Anna Poscher, Eszter Anna Váradi, Gyöngyi Cinege, Antal Izsán, Edina Erdős, Bernadett Benyhe-Kis, Anna Zsuzsanna Tihanyi, Petros Tzerpos, Krisztián Bene, László Halász, Nikolett Gémes, Patrícia Neuperger, Márta Tóth, Ede Migh, Szilárd Póliska, Gábor J Szebeni, Jolán E Walter, Bence Dániel, Bálint Csörgő, László Nagy, Zsolt Czimmerer |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 76 KB |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |