Annona muricata Polyphenols Induce Cytoskeletal Alterations and Predicted Aldose Reductase Binding in Giardia lamblia
Diana Valeria Govea-Flores, Mariana Garza-Ontiveros, Filiberto Gutiérrez-Gutiérrez, Ana Gabriela Gómez-Ibarra, Sendar Daniel Nery-Flores, Juan Alberto Ascacio-Valdés, Lizeth Guadalupe Campos-Múzquiz, Raúl Rodríguez-Herrera, Lissethe Palomo-Ligas · 2026
Read Annona muricata Polyphenols Induce Cytoskeletal Alterations and Predicted Aldose Reductase Binding in Giardia lamblia by Diana Valeria Govea-Flores, Mariana Garza-Ontiveros, Filiberto Gutiérrez-Gutiérrez, Ana Gabriela Gómez-Ibarra, Sendar Daniel Nery-Flores, Juan Alberto Ascacio-Valdés, Lizeth Guadalupe Campos-Múzquiz, Raúl Rodríguez-Herrera, Lissethe Palomo-Ligas (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13507698.txt.
Description
Diana Valeria Govea-Flores and co-authors test soursop compounds against a gut parasite in this 2026 study. The parasite, Giardia lamblia, causes a disease the World Health Organization counts as neglected. Drug resistance and failed treatments keep the search for new agents alive.
Plant compounds have a proud record here, from quinine to artemisinin. The team dosed the parasite with polyphenols from Annona muricata, the soursop tree. The compounds warped the parasite's skeleton of protein struts. Computer docking predicted they also grip an enzyme, aldose reductase. The double hit, structural damage plus a named target, makes the plant a lead worth chasing.
Catalog record
| CREATOR | Diana Valeria Govea-Flores, Mariana Garza-Ontiveros, Filiberto Gutiérrez-Gutiérrez, Ana Gabriela Gómez-Ibarra, Sendar Daniel Nery-Flores, Juan Alberto Ascacio-Valdés, Lizeth Guadalupe Campos-Múzquiz, Raúl Rodríguez-Herrera, Lissethe Palomo-Ligas |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 47 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |