RANBP3 promotes mitophagy through the CCAR2/SIRT1 pathway to alleviate pyroptosis in macrophages in TBTB
Lei Zhou, Lin-Zi Luo, Zhi-Bin Lu, Hai-Long Luo, Dan Feng, Limei Gong, Yang-Bao Xiao, Li Luo · 2026
Read RANBP3 promotes mitophagy through the CCAR2/SIRT1 pathway to alleviate pyroptosis in macrophages in TBTB by Lei Zhou, Lin-Zi Luo, Zhi-Bin Lu, Hai-Long Luo, Dan Feng, Limei Gong, Yang-Bao Xiao, Li Luo (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13507262.txt.
Description
Lei Zhou leads a 2026 team that links the protein RanBP3 to protection against tracheobronchial tuberculosis, a form of TB infecting the windpipe and airways. In this disease, infected macrophages often die by pyroptosis, a fiery death that spreads inflammation and helps bacteria escape. RanBP3 levels fell in diseased airway tissue.
Raising RanBP3 in mouse macrophages boosted mitophagy, the disposal of worn mitochondria, and calmed pyroptosis while cutting bacterial survival. RanBP3 frees the enzyme SIRT1 from its holder CCAR2, and freed SIRT1 switches on the cleanup. Blocking SIRT1 erased the benefit in animals. The axis offers a fresh drug target for airway TB.
Catalog record
| CREATOR | Lei Zhou, Lin-Zi Luo, Zhi-Bin Lu, Hai-Long Luo, Dan Feng, Limei Gong, Yang-Bao Xiao, Li Luo |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 56072 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |