Compensatory coupling between leak and HCN conductances defines a low dimensional solution manifold in GPe neuron subtypes
Matheus Phellipe Brasil de Sousa, Gabriel Moreno Cunha, Gabrielle Emily Boaventura Tavares, Gilberto Corso, Karina Possa Abrahao, Gustavo Zampier dos Santos Lima · 2026
Read Compensatory coupling between leak and HCN conductances defines a low dimensional solution manifold in GPe neuron subtypes by Matheus Phellipe Brasil de Sousa, Gabriel Moreno Cunha, Gabrielle Emily Boaventura Tavares, Gilberto Corso, Karina Possa Abrahao, Gustavo Zampier dos Santos Lima (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13507147.txt.
Description
Matheus Phellipe Brasil de Sousa leads a 2026 modeling study of two neuron types in the globus pallidus externa, a basal ganglia hub for movement control. Prototypical and arkypallidal neurons fire at different rates and respond differently to voltage dips. The team varied two ion flows in a cell model: a steady leak flow and HCN flow, which turns on after voltage dips.
Measured traits such as firing rate, sag ratio, and trough depth were matched to lab benchmarks. Valid settings revealed a trade-off curve where leak and HCN strengths balance each other in opposite directions. Staying on that curve preserves healthy firing through varied channel mixes. Drifting off it may explain faulty firing in Parkinson disease circuits.
Catalog record
| CREATOR | Matheus Phellipe Brasil de Sousa, Gabriel Moreno Cunha, Gabrielle Emily Boaventura Tavares, Gilberto Corso, Karina Possa Abrahao, Gustavo Zampier dos Santos Lima |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 66489 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |