Antioxidant malic-acid-derived lipid nanoparticles delivering secretory uricase circRNA for hyperuricemia and complication management in mice
Keqian Du, Yiming Guo, Junjie Zhou, Yaping Liu, Lin Jiang, Dawei Hua, Di Zhang, Yuqi Zhang, Zijian Deng, Xingyu Zheng, Jianping Guo, Jing Ni, Yingjie Li, Shichao Sun, Zhiming Lin, Jianlin Huang, Lin-Ping Wu · 2026
Read Antioxidant malic-acid-derived lipid nanoparticles delivering secretory uricase circRNA for hyperuricemia and complication management in mice by Keqian Du, Yiming Guo, Junjie Zhou, Yaping Liu, Lin Jiang, Dawei Hua, Di Zhang, Yuqi Zhang, Zijian Deng, Xingyu Zheng, Jianping Guo, Jing Ni, Yingjie Li, Shichao Sun, Zhiming Lin, Jianlin Huang, Lin-Ping Wu (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13507142.txt.
Description
Keqian Du leads a 2026 team that designs fat particles to deliver circular RNA for treating high uric acid and its complications, such as gout and kidney damage. Humans lack uricase, an enzyme that breaks down uric acid, and injected enzyme fades fast and provokes immunity. Their particles use lipids built from malic acid, a mild natural acid with calming effects.
Screening picked a lead particle that entered cells well, stirred little immune response, and added antioxidant action. In male mice, the system gave lasting uric acid cuts, eased joint pain and tissue scarring, and protected kidney function. Circular RNA lasts longer than standard RNA, which supports durable effect from each dose.
Catalog record
| CREATOR | Keqian Du, Yiming Guo, Junjie Zhou, Yaping Liu, Lin Jiang, Dawei Hua, Di Zhang, Yuqi Zhang, Zijian Deng, Xingyu Zheng, Jianping Guo, Jing Ni, Yingjie Li, Shichao Sun, Zhiming Lin, Jianlin Huang, Lin-Ping Wu |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 97338 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |