CD49a+ NK cells promote M2 polarization and are associated with poor pathological response in NSCLC
Xin Li, Zelin Zhao, Weihong Zhang, Meng Wang, Siyuan Zhang, Nan Dong, Wenwen Yu, Yang An, Xiubao Ren, Hua Zhao, Yu Zhang · 2026
Read CD49a+ NK cells promote M2 polarization and are associated with poor pathological response in NSCLC by Xin Li, Zelin Zhao, Weihong Zhang, Meng Wang, Siyuan Zhang, Nan Dong, Wenwen Yu, Yang An, Xiubao Ren, Hua Zhao, Yu Zhang (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13507088.txt.
Description
Xin Li and colleagues report 2026 findings on a tissue-resident natural killer cell group in non-small cell lung cancer, the most common lung cancer type. Natural killer cells normally kill tumor cells, yet this group, marked by CD49a, behaved in a suppressive way. The team studied surgical samples with single-cell gene readings.
Tumors rich in these cells responded poorly to therapy given before surgery and held fewer tertiary lymphoid structures, small immune hubs linked to better outcomes. The cells showed high checkpoint genes, low killing genes, and high CSF-1 output. That signal pushed macrophages toward a healing M2 state that favors tumors. Blocking this group could improve pre-surgery therapy.
Catalog record
| CREATOR | Xin Li, Zelin Zhao, Weihong Zhang, Meng Wang, Siyuan Zhang, Nan Dong, Wenwen Yu, Yang An, Xiubao Ren, Hua Zhao, Yu Zhang |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 40834 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |