scRNA-seq analysis shows neutrophil extracellular traps as drivers of obstruction-induced intestinal damage in rats
Zhanchuan Li, Yongxin Ye, Peng Wang, Fei Long, Yingyi Zhang, Xunri Zheng, Changwei Lin, Xiaorong Li, Yang Bai, Yi Zhang · 2026
Read scRNA-seq analysis shows neutrophil extracellular traps as drivers of obstruction-induced intestinal damage in rats by Zhanchuan Li, Yongxin Ye, Peng Wang, Fei Long, Yingyi Zhang, Xunri Zheng, Changwei Lin, Xiaorong Li, Yang Bai, Yi Zhang (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13507056.txt.
Description
Zhanchuan Li and co-authors report a 2026 study of gut damage when the bowel is blocked in rats. A blocked bowel is a common surgical emergency that can turn deadly fast. The cell level steps that break the gut wall in such cases were not well mapped.
The team read gene activity cell by cell in more than 23,000 gut cells. White blood cells flooded the tissue at late stages, and one subset was tied to web like traps those cells cast out. The traps built up over time as wall seal proteins fell. A drug that blocks trap formation cut the traps, eased tissue harm, and lowered two swelling signals. The work names the traps as a treatment target.
Catalog record
| CREATOR | Zhanchuan Li, Yongxin Ye, Peng Wang, Fei Long, Yingyi Zhang, Xunri Zheng, Changwei Lin, Xiaorong Li, Yang Bai, Yi Zhang |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 65 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |