Prostaglandin E2 modulates contractility of mouse bladder smooth muscle cells
Rok Šumak, Igor But, Andraž Stožer, Jurij Dolenšek, Tamara Serdinšek · 2026
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Description
A peer-reviewed research article from Europe PMC (2026). BackgroundProstaglandin E2 (PGE2) is an important local mediator in the urinary bladder, where it contributes to the regulation of detrusor excitability and is implicated in pathological conditions such as overactive bladder. Although previous studies have shown that exogenous PGE enhances bladder contractile activity, its effects on calcium signaling in individual detrusor smooth muscle cells (SMCs) and its interaction with cholinergic stimulation remain incompletely understood.MethodsAcute detrusor tissue slices were prepared from adult female NMRI mice and loaded with the calcium indicator Calbryte 520
Catalog record
| CREATOR | Rok Šumak, Igor But, Andraž Stožer, Jurij Dolenšek, Tamara Serdinšek |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 41 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |