Nanopore and EPIC array profiling unmask an atypical non-midline H3 K27-altered glioma: a case report
Michela Buonaiuto, Pasqualina Giordano, Alfredo D’Avino, Ornella Affinito, Mariella Cuomo, Marta Sabbarese, Angela Viggiano, Francesca Maria Giugliano, Alberto Negro, Federico Frio, Giuseppe Catapano, Lorenzo Chiariotti, Rosa Della Monica · 2026
Read Nanopore and EPIC array profiling unmask an atypical non-midline H3 K27-altered glioma: a case report by Michela Buonaiuto, Pasqualina Giordano, Alfredo D’Avino, Ornella Affinito, Mariella Cuomo, Marta Sabbarese, Angela Viggiano, Francesca Maria Giugliano, Alberto Negro, Federico Frio, Giuseppe Catapano, Lorenzo Chiariotti, Rosa Della Monica (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13506394.txt.
Description
We report a rare case of Diffuse Midline Glioma, H3K27-altered, arising in a non-midline fronto-temporo-insular location in a 48-year-old adult, initially mimicking Glioblastoma, IDH-wildtype, based on radiology and histopathology. Integrated molecular diagnostics, including genome-wide DNA methylation profiling and Sanger sequencing, confirmed an H3.
Catalog record
| CREATOR | Michela Buonaiuto, Pasqualina Giordano, Alfredo D’Avino, Ornella Affinito, Mariella Cuomo, Marta Sabbarese, Angela Viggiano, Francesca Maria Giugliano, Alberto Negro, Federico Frio, Giuseppe Catapano, Lorenzo Chiariotti, Rosa Della Monica |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 23 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |