Caffeine and 4‐Hydroxybenzoic Acid Cocrystal Hydrate: Preparation, Characterization, and Evaluation
Shagun Gogna, Jonathan J. Du, Paul W. Groundwater, Mohamed Fares, Philip Chi Lip Kwok, Grace Tsz Yan Yau, Jan‐Willem C. Alffenaar, David E. Hibbs · 2026
Read Caffeine and 4‐Hydroxybenzoic Acid Cocrystal Hydrate: Preparation, Characterization, and Evaluation by Shagun Gogna, Jonathan J. Du, Paul W. Groundwater, Mohamed Fares, Philip Chi Lip Kwok, Grace Tsz Yan Yau, Jan‐Willem C. Alffenaar, David E. Hibbs (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13506356.txt.
Description
Gogna and colleagues prepared and evaluated a cocrystal hydrate pairing caffeine with 4-hydroxybenzoic acid, in a 2026 study aimed at taming caffeine's uneven behavior in the body. Caffeine's solubility swings widely with acidity and its stability is moderate, limiting absorption predictability. Growing the two compounds together with water in a one-to-one-to-one ratio yields a new crystal form held together by hydrogen bonds.
Gogna confirmed the crystal's structure by X-ray methods, finding a distinct melting point well below either parent compound and little mass loss before melting, indicating purity and thermal stability. Surface analysis showed a larger share of hydrogen-oxygen contacts than in pure caffeine, explaining the lattice's cohesion. Dissolution tests found the cocrystal reshaped release timing rather than total solubility. Release started slowly in stomach-like acid then completed, while in intestinal-like conditions it released fully within an hour, slightly faster than pure caffeine.
Catalog record
| CREATOR | Shagun Gogna, Jonathan J. Du, Paul W. Groundwater, Mohamed Fares, Philip Chi Lip Kwok, Grace Tsz Yan Yau, Jan‐Willem C. Alffenaar, David E. Hibbs |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 49 KB |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |