miR-889-3p targets SLC35E1 in leprosy: Implications for therapeutic monitoring
Yang Li, Lei Chen, Zepu Guan, Liting Cai, Buning Ye, Xiaohua Wang · 2026
Read miR-889-3p targets SLC35E1 in leprosy: Implications for therapeutic monitoring by Yang Li, Lei Chen, Zepu Guan, Liting Cai, Buning Ye, Xiaohua Wang (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13505911.txt.
Description
Leprosy still lacks good markers for tracking whether treatment is working. Six authors hunted through small RNA regulators in patients' skin, blood, and nasal samples, comparing the severe and mild forms of the disease with healthy controls. One regulator stood out: miR-889-3p, raised in every sample type from severe cases.
After standard multidrug therapy, its level fell back toward healthy values, following the bacterial load down. Lab assays showed the regulator binds the message of a gene called SLC35E1 in a sequence-specific way. The gene's protein, in turn, ran high in lesions and tracked the bacterial index closely. The authors propose the small RNA as a blood-and-tissue gauge of treatment response. The pair it forms with its target gene is offered as a new window on how the host answers the infection.
Catalog record
| CREATOR | Yang Li, Lei Chen, Zepu Guan, Liting Cai, Buning Ye, Xiaohua Wang |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 33 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |