Durability of response to icotrokinra for high‐impact site psoriasis: 1‐year ICONIC‐TOTAL findings
Richard B. Warren, Melinda Gooderham, Edward Lain, Robert Bissonnette, Yu‐Huei Huang, Julien Ringuet, Matthias Hoffmann, Andreas Pinter, Joseph F. Merola, Jessica H. Rubens, Dorothy Fan, Ming‐Chun Hsu, Shu Li, Ya‐Wen Yang, Cynthia M. C. DeKlotz, Eingun James Song · 2026
Read Durability of response to icotrokinra for high‐impact site psoriasis: 1‐year ICONIC‐TOTAL findings by Richard B. Warren, Melinda Gooderham, Edward Lain, Robert Bissonnette, Yu‐Huei Huang, Julien Ringuet, Matthias Hoffmann, Andreas Pinter, Joseph F. Merola, Jessica H. Rubens, Dorothy Fan, Ming‐Chun Hsu, Shu Li, Ya‐Wen Yang, Cynthia M. C. DeKlotz, Eingun James Song (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13505761.txt.
Description
Richard B. Warren and others report one-year results for icotrokinra in high-impact site scaly skin. In 2026, the phase 3 ICONIC-TOTAL trial randomized people aged twelve or older with at least modest scalp, genital, or hand and foot scaly skin two-to-one. They got once-daily oral icotrokinra 200 milligrams or placebo. Those on placebo switched at week sixteen. High-impact sites are notoriously hard to treat.
Eighty-eight percent completed treatment through week fifty-two. Clear or almost clear rates rose through week twenty-four and held through week fifty-two. They ranged 67 to 70 percent overall, 72 to 78 percent for scalp, 85 to 90 percent for genital, and 54 to 62 percent for hand and foot disease. Nail improvement rose from thirty-three to sixty-two percent. Adverse event rates matched placebo with no new safety signal.
Catalog record
| CREATOR | Richard B. Warren, Melinda Gooderham, Edward Lain, Robert Bissonnette, Yu‐Huei Huang, Julien Ringuet, Matthias Hoffmann, Andreas Pinter, Joseph F. Merola, Jessica H. Rubens, Dorothy Fan, Ming‐Chun Hsu, Shu Li, Ya‐Wen Yang, Cynthia M. C. DeKlotz, Eingun James Song |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 45 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |