Characterization of Ovarian Cell Types and Molecular Signatures in Mauremys reevesii Using Single‐Cell Sequencing
Kaiqi Yuan, Xin Niu, Yue Yuan, Jiale Zhou, Meiling Hong, Li Ding · 2026
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Description
Yuan and colleagues produced the first single-cell atlas of the ovary of the Chinese pond turtle, Mauremys reevesii, in a 2026 sequencing study. Turtle reproductive biology has centered on temperature-driven sex determination. That focus leaves the ovary's cell makeup and its signaling largely unknown, a gap that limits ecology and conservation planning for these animals. The team sequenced RNA from ovarian cells and grouped them by gene activity.
Yuan resolved six lineages, including egg cells, the granulosa cells that nurse them, immune cells, vessel cells, and fibroblasts, and reconstructed the signaling web between them. Cross-species comparison confirmed classic markers. Two signaling proteins, WNT4 and WNT6, emerged as specific signatures of turtle granulosa cells, verified by tissue staining, and another protein marked the eggs. The authors present the atlas as a foundation for understanding turtle reproduction and for conservation of pond turtles and relatives.
Catalog record
| CREATOR | Kaiqi Yuan, Xin Niu, Yue Yuan, Jiale Zhou, Meiling Hong, Li Ding |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 35 KB |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |